IRB Reliance with Children’s Hospital of Orange County (CHOC) and MemorialCare Health System (MHS)

To:                          UCI Researchers


From:                    UCI Office of Research, Human Research Protections


Children’s Hospital of Orange County (CHOC), MemorialCare Health System (MHS) and UCI Irvine (UCI) have entered into an agreement that allows human subjects research to be reviewed by one IRB when two or more institutions are engaged in the same human subject research. This IRB reliance relationship (referred to as the “CMU IRB Reliance”), whereby one IRB serves as the Reviewing IRB, and other IRBs rely on that review, is intended to streamline the process by avoiding duplication of effort.


Beginning June 10, 2013, we would like to pilot this process by accepting up to five (5) new IRB applications that involve two or more CMU performance sites or amendments to add a CMU institution to an existing IRB-approved protocol.


The CMU IRB Reliance web page: provides instructions on how to participate in this pilot.  A few anticipated questions are also available on the FAQs page located on the IRB reliance web page.  If you have further questions, please contact me, Beverley Williams (, or Jessica Sheldon (


Information gathered from the pilot will be used to refine the CMU IRB Reliance process in preparation for an official launch in August 2013.  We are excited about this IRB collaboration and look forward to working with our CHOC and MHS colleagues.


Karen Allen

Director, Research Protections

UC Irvine, Office of Research

(949) 824-1558

pdf icon CMU-IRB-Reliance-Announcement-06-05-13.pdf

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