Notice of Impending Change in Peer Review Criteria and Submission
Requirements for NIH Applications Involving Human Embryonic Stem Cells

NOT-NS-12-111
http://grants.nih.gov/grants/guide/notice-files/NOT-OD-12-111.html

Summary: Beginning with applications submitted for the September 25,
2012 due date and thereafter, applications proposing the use of hESC
must:

* Specify a cell line(s) from the NIH Stem Cell Registry (which
now lists over 160 approved cell lines) that will be used in the
proposed research, or

* Provide a strong justification for why an appropriate cell
line cannot be chosen from the Registry at this time and a certification
that one from the Registry will be used. The justification should be
included in the Research Strategy section of the application.

Reviewers will be instructed to evaluate the scientific appropriateness
of the proposed cell line(s)… If the proposed cell line(s) is
approved by the NIH Stem Cell Registry at least 30 days prior to the
peer review meeting, the SRO can include this update to the reviewers as
part of the post-submission materials (see NOT-OD-10-115
http://grants.nih.gov/grants/guide/notice-files/NOT-OD-10-115.html ).
This evaluation will be allowed to affect individual criterion scores,
assessments of overall merit, and overall impact scores during initial
peer review.

As before, if an hESC application proposes research for which the
specified hESC line(s) has not yet been approved, only restricted awards
will be issued until the specified hESC line(s) is approved.

Department Administrators: Please redistribute this message, as
appropriate, to faculty and researchers in your department.

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