NIH recently published guidance to assist the extramural research community in addressing rigor and reproducibility in grant applications as well as examples of rigorous experimental design from funded applications. http://grants.nih.gov/reproducibility/index.htm.
NIH also recently released a training module developed for NIH staff (https://grants.nih.gov/reproducibility/module_1/presentation.html) that provides a comprehensive overview of revisions to NIH policy, grant application instructions, and review criteria for rigor and reproducibility.
These resources are also available on the School of Medicine Office of Research Enhancing Rigor and Reproducibly resource page (http://som.uci.edu/research/enhancing-rigor-and-reproducibility.asp).