NIH Guide Notice Updates

Dear Colleagues:

Below is a summary of recent NIH Guide Notices. Please review the notices and forward them to faculty, researchers and staff, as appropriate. Questions regarding the notices should be directed to your Contract and Grant Officer.

This notice provides an overview of application and peer review changes impacting      grant applications submitted for due dates on or after January 25, 2025, including:

  • Simplified Review Framework for Most Research Project Grant Applications
  • Revisions to the NIH Fellowship Application and Review Process 
  • Updates to Reference Letter Guidance
  • Updates to NRSA Training Grant Applications
  • Updated Application Forms (FORMS-I)
  • Common Forms for Biographical Sketch and Current and Pending (Other) Support
Please review the notice for detailed information regarding the changes. Please note that the notice also provides resources and dates for webinars to review the changes.

This notice provides an update and implementation plans for the simplified framework for peer review for the majority of research project grant applications announced in October (NOT-OD-24-010). It updates and clarifies impacted activity codes, plans for updating funding opportunities, and timing for application forms availability.

NIH remains on schedule to implement the simplified review framework for application due dates on or after January 25, 2025.

Please review the notice for additional information regarding the update and implementation plans.

This notice provides information regarding changes to grant application forms and application guide instructions for due dates on or after January 25, 2025.

The following application forms include substantive form changes (i.e., new/deleted/modified fields). 

  • PHS 398 Research Training Program Plan
  • PHS Fellowship Supplemental Form
  • PHS Assignment Request Form
  • PHS 398 Cover Page Supplement Form

Key Changes:

  • A new attachment field for the Recruitment Plan to Enhance Diversity on the PHS 398 Research Training Program Plan. Additional changes for institutional training grants will be detailed via NIH Guide notice by late spring 2024.
  • As part of NIH efforts to improve the peer review process for NRSA Fellowship applications, there will be modifications to some sections of the PHS Fellowship Supplement Form. Additional details will be provided via an NIH Guide notice by late spring 2024.
  • NIH adoption and required use of the Common Forms for Biographical Sketch and Current and Pending (Other) Support by May 2025. Additional details will be communicated via NIH Guide notice by summer 2024. 
Please review the notice for additional information regarding the FORMS-I grant application implementation.
Nancy Lewis
Senior Director, Sponsored Projects Administration
Office of Research
University of California, Irvine
160 Aldrich Hall
Irvine, CA 92697-7600
Ph-(949) 824-2897

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