NIH Funding Opportunities and Notices for 05-09-2025 (The NIH Guide TOC)

Dear Colleagues,

Below is a summary of recent NIH policy notice. Please review the notices and forward it to faculty, researchers, and staff, as appropriate. Questions regarding the notices should be directed to your Federal Contract and Grant Officer.

Updated NIH Processes for No-Cost Extensions
(NOT-OD-25-110)
National Institutes of Health

• This notice alerts the extramural community that NIH has temporarily disabled the No-Cost Extension functionality in eRA Commons. The Director of NIH has directed NIH staff to review all existing grants and cooperative agreements to ensure that NIH awards do not fund off-mission activities or projects. At this time, all requests for NCEs must be submitted as a prior approval request in eRA Commons, for NIH review and approval. 

Implementation Update: Improving the Safety and Security of Biological Research
(NOT-OD-25-112)
National Institutes of Health

• Policies, actions, and definitions defined in this Executive Order supersede NIH’s implementation of the White House Office of Science and Technology Policy (OSTP) May 2024 U.S. Government Policy for Oversight of Dual Use Research of Concern and Pathogens with Enhanced Pandemic Potential (DURC/PEPP Policy). Accordingly, NIH is rescinding NOT-OD-25-061.
• NIH will not accept competitive applications for grants and cooperative agreements submitted for due dates after today and/or R&D contract proposals submitted to solicitations issued after today for dangerous gain-of-function research, as defined in Section 8 of the Executive Order.
• NIH intends to suspend ongoing funding in accordance with guidance developed under Section 3(b) of the Executive Order. All NIH awardees should review ongoing research activities to proactively identify potential dangerous gain-of-function research and identify safe actions to halt such research and to effectively comply with guidance once established.

Regards,